Mesenchymal Stem Cell Therapy Applications

After isolation the cells are expanded and characterized to prove their mesenchymal nature.

Mesenchymal stem cell therapy applications.

Allograft bone products containing viable stem cells including but not limited to demineralized bone matrix with stem cells are considered investigational for all orthopedic applications. Allograft bone products containing viable stem cells including but not limited to demineralized bone matrix with stem cells are considered experimental. Mesenchymal stem cells mscs bear a variety of properties such as the ability to differentiate into various cell lineages to secrete soluble factors crucial for cell survival and proliferation to migrate to the exact site of injury and to modulate the immune response. Mesenchymal stem cells have the capacity to become any type of fully developed cell which can contribute to replacing muscle tissues or internal organs.

Isolation characterization and potential applications of bovine mesenchymal stem cells. Mesenchymal stem cell therapy is considered investigational for all orthopedic applications including use in repair or regeneration of musculoskeletal tissue. Mscs are investigational products that have been studied extensively for broad clinical applications in regenerative medicine1 and for their immunomodulatory properties 2no mscs are approved by the food and drug administration fda for the treatment of covid 19. Mesenchymal stem stromal cells mscs are multipotent cells with the ability to differentiate into several cell types thus serving as a cell reservoir for regenerative medicine.

This coverage policy addresses stem cell therapy for orthopaedic applications in particular mesenchymal stem cells mscs. Bovine mesenchymal stem cells have been isolated from the uterus umbilical cord bone marrow adipose tissue placenta and fetal fluids. Mscs have been proposed as a type of regenerative therapy. Much of the current interest in therapeutic application of mscs to various disease settings can be linked to their immunosuppressive and anti inflammatory properties.

Regenerative therapy is considered an emerging field of medicine focusing on repair replacement or regeneration of cells and tissues. Mesenchymal stem stromal cells are one of the most commonly studied stem cell populations and the most commonly used cell based therapy for neurodegenerative cardiovascular and other diseases in clinical trials because of their regenerative effects. To help discover the therapeutic uses of these stem cells they are grown in laboratories or by using medication to stimulate new cell growth within. Among all kinds of stem cells mesenchymal stem cells mscs have been shown to be an interesting therapeutic option due to their immunomodulatory properties and their potential for in vitro differentiation into insulin secreting cells.